![]() The flexibility of user-defined models allows continuous refinement of the model as new experimental information becomes available. The mathematical method employed should be reviewed before use.įitting data into a pharmacokinetic or pharmacodynamic model defined by the user: This method is by far the most useful, because any list of prepared models is often limited. Some data may allow easier convergence with one procedure rather than another. Usually, a mathematical procedure is used iteratively (repetitively) to achieve a minimum in the sum of squares (convergence). Fitting drug concentration–time data to a series of pharmacokinetic models, and choosing the one that best describes the data statistically: Typically, a least-squares program is employed, in which the sum of squared differences between observed data points and theoretic prediction is minimized.
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